Hypothermic Versus Normothermic Temperature Control After Cardiac A sensitivity analysis excluding the targeted hypothermia vs targeted normothermia after out of hospital cardiac arrest (ttm2) trial showed resolution of the observed heterogeneity, and demonstrated significantly higher rates of favorable neurological outcome with hypothermia vs normothermia (rr 1.45; 95% ci, 1.17 1.79; p < .001, i 2 = 1%). 10. Background: the role of targeted hypothermia in patients with coma after cardiac arrest has been challenged in a recent randomized clinical trial. methods: we performed a computerized search of medline, embase, and cochrane databases through july 2021 for randomized trials evaluating the outcomes of targeted hypothermia vs normothermia in patients with coma after cardiac arrest with shockable.
Targeted Hypothermia Vs Targeted Normothermia In Survivors Of ођ A recent trial involving patients who had cardiac arrest with nonshockable rhythm showed better neurologic outcomes with targeted hypothermia at 33°c than with targeted normothermia at 37°c. 5. Hypothermia was recommended in international guidelines as a neuroprotective strategy for those unconscious after out of hospital cardiac arrest (ohca), 1 3 but based on low certainty evidence. 2,4 the targeted hypothermia vs targeted normothermia after out of hospital cardiac arrest (ttm2) trial 5 reported no difference in mortality or poor. The current american heart association 2022 guidelines recommend actively preventing fever by targeting a temperature ≤37.5°c for comatose patients after cardiac arrest. contemporary randomized controlled trials (rcts) show conflicting results regarding the benefit of targeted hypothermia (th). we performed this updated meta analysis of rcts to evaluate the role of hypothermia in patients. To address this, the hypothermia versus normothermia after out of hospital cardiac arrest (ttm2) trial compared a target temperature of 33°c with normothermia in participants with out of hospital cardiac arrest. 8 normothermia was defined as a temperature of 37.8°c or lower, and a temperature above this triggered the use of a temperature.
Ttm2 Hypothermia Vs Normothermia For Out Of Hospital Cardiac Arrest The current american heart association 2022 guidelines recommend actively preventing fever by targeting a temperature ≤37.5°c for comatose patients after cardiac arrest. contemporary randomized controlled trials (rcts) show conflicting results regarding the benefit of targeted hypothermia (th). we performed this updated meta analysis of rcts to evaluate the role of hypothermia in patients. To address this, the hypothermia versus normothermia after out of hospital cardiac arrest (ttm2) trial compared a target temperature of 33°c with normothermia in participants with out of hospital cardiac arrest. 8 normothermia was defined as a temperature of 37.8°c or lower, and a temperature above this triggered the use of a temperature. Abstract. targeted temperature management (ttm), specifically therapeutic hypothermia, has been proposed to provide neuroprotective and mortality benefits for out of hospital cardiac arrest (ohca) survivors. this proposition was based on small scale trials from the early 2000s, leading to its incorporation into various international guidelines. In this meta analysis of 8 randomized clinical trials including 2927 patients who remained unconscious after successful resuscitation from cardiac arrest, we compared the effects of targeted hypothermia (32 34°c) vs targeted normothermia (∼37°c) on overall survival and neurological outcomes.
Hypothermia Vs Normothermia After Out Of Hospital Cardiac Arrest New Abstract. targeted temperature management (ttm), specifically therapeutic hypothermia, has been proposed to provide neuroprotective and mortality benefits for out of hospital cardiac arrest (ohca) survivors. this proposition was based on small scale trials from the early 2000s, leading to its incorporation into various international guidelines. In this meta analysis of 8 randomized clinical trials including 2927 patients who remained unconscious after successful resuscitation from cardiac arrest, we compared the effects of targeted hypothermia (32 34°c) vs targeted normothermia (∼37°c) on overall survival and neurological outcomes.
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