Schematic Representation Of Multiple Myeloma Mm Cell Metabolism

Schematic Representation Of Multiple Myeloma Mm Cell Metabolism Download scientific diagram | schematic representation of multiple myeloma (mm) cell metabolism compared to normal plasma cells. flow of metabolites is shown by colored arrows. glycolysis, oxphos. Schematic presentation of targets in glucose and glutamine metabolism in mm cells. metabolic rearrangements in mm cells after administering compounds inducing stimulation or inhibition. 3bp enters the cell through mct4 and inhibits hkii connected to the outer mitochondrial membrane via vdac leading to atp reduction and the loss of viable cells. 2dg enters the cell through glut and is.

Schematic Representation Of Multiple Myeloma Mm Cell Metabolism Introduction. multiple myeloma (mm) is a cancer of plasma cells, the terminally differentiated effector cells of the humoral immune system whose main function is the provision of immunoglobulins. to fulfil this task, plasma cells dispose of a well developed organellar apparatus that enables them to assemble and secrete large amounts of protein. Multiple myeloma (mm) is a malignant expansion of plasma cells in the bone marrow (bm), resulting in a disease characterized by symptoms of end organ damage from light chain secretion, crowding of. Multiple myeloma (mm) is the second most common hematologic malignancy and is attributed to bone marrow infiltration by monoclonal plasma cells. the plasma cell proliferation in the marrow leads to increased production and circulation of the monoclonal paraprotein (m spike) in serum and or urine [1]. the cardinal clinical features of mm include. Multiple myeloma (mm) is a plasma cell malignancy that is often driven by chromosomal translocations. a schematic representation of the mva pathway and its sterol regulated feedback loop.