Frontiers Targeting The Innate Immune System As Immunotherapy For

Frontiers Targeting The Innate Immune System As Immunotherapy For The innate immune system appears to play a key role in immune evasion by aml and thus, activating innate immunity will likely be critical in immunotherapeutic strategies for this disease. further insight into the unique mechanisms of immune evasion in aml is needed, but early data suggest promising immunotherapeutic approaches with tlr agonists. These data are impor tant because they suggest that immune tolerance to aml may be initiated at the level of the innate immune system. inflammatory cytokines, chemokines, mhc, and costimulatory molecules (24). there are at least 10 tlrs in humans and several, including tlr3, have been targeted as immunotherapy for cancer.

Frontiers Targeting Innate Immunity In Breast Cancer Therapy A Targeting these unique mechanisms may result in improved immunotherapeutic approaches. emerging data suggest that a specific dendritic cell (dc) subset, cd8α dcs, may be responsible for mediating tolerance in aml and thus targeting the innate immune system may be of benefit in this disease. 1 introduction. immunotherapy is one of the most effective approaches for the treatment of cancer. immune checkpoint blockade (icb) therapies, such as programmed cell death protein 1 (pd 1) programmed cell death ligand 1 (pd l1) inhibitors and cytotoxic t lymphocyte associated protein 4 (ctla 4) inhibitors, have exhibited promising therapeutic effects in the treatment of various malignancies. The innate immune system is critical for inducing durable and protective t cell responses to infection and has been increasingly recognized as a target for cancer immunotherapy. in this review, we present a framework wherein distinct innate immune signaling pathways activate five key dendritic cell activities that are important for t cell. A large proportion of immune cells in and around solid tumors derive from the innate arm of the immune system, and using these innate cells against tumors offers an alternative immunotherapeutic.