D0 B2 D1 81 D0 B5 D0 Bc D0 B8 D1 80 D0 Bd Background: advances in radiotherapy for thoracic cancers have resulted in improvement of survival. however, radiation exposure to the heart can induce cardiotoxicity. no therapy is currently available to inhibit these untoward effects. we examined whether a small tetrapeptide, n acetyl ser asp lys pro (ac sdkp), can counteract radiation induced cardiotoxicity by inhibiting macrophage. General aspects of thymosin β4 (tβ4)– n acetylseryl aspartyl lysyl proline (ac sdkp) tβ4 is an endogenous 43 amino acid peptide, first isolated in the thymus and subsequently found in the blood circulation, urine, and various organs, including the heart and kidneys ( mora et al. 1997 ). tβ4 was best known for its g actin sequestering.
рљрѕрїрёсџ рірёрґрµрѕ D0 B6 D0 B5 D0 Bd D1 81 D0 Ba D0о Cardiovascular diseases (cvds) represent ∼31% of all global deaths, and hypertension alone accounts for ∼50% of these cases. inflammation and subsequent fibrosis in heart, kidney and brain are associated with increased morbidity and mortality in cvd patients. n acetyl seryl aspartyl proline (ac sdkp …. Thymosin β4 (tβ4) is a 43 amino acid short peptide that was originally described to regulate lymphocyte maturation in the thymus, 4 and subsequently, tβ4 was identified as a primary g actin–sequestering peptide. 5 tβ4 is highly expressed in platelets, macrophages, and wound fluids. 6,7 tβ4 is also found in other tissues of the body, including heart and kidney. 8 our group recently. We concluded that ac sdkp has protective effects against radiation induced reduction of myocardial blood flow. such protective effects are likely mediated by neutralization of ros mediated injury, preservation of endothelial integrity and inhibition of fibrosis. this demonstrates a strong therapeuti …. Conclusions. our study identifies novel cardioprotective effects of ac sdkp in a model of cardiac irradiation. these protective effects are exerted by inhibiting inflammation, fibrosis, and reducing macrophage activation. this study shows a therapeutic potential of this endogenously released peptide to counteract radiation induced cardiomyopathy.
D0 A1 D0 Bf D0 B0 D1 81 D0 B6 D0 B8 D0 Bb We concluded that ac sdkp has protective effects against radiation induced reduction of myocardial blood flow. such protective effects are likely mediated by neutralization of ros mediated injury, preservation of endothelial integrity and inhibition of fibrosis. this demonstrates a strong therapeuti …. Conclusions. our study identifies novel cardioprotective effects of ac sdkp in a model of cardiac irradiation. these protective effects are exerted by inhibiting inflammation, fibrosis, and reducing macrophage activation. this study shows a therapeutic potential of this endogenously released peptide to counteract radiation induced cardiomyopathy. Biomaterials in conjunction with stem cell therapy have recently attracted attention as a new therapeutic approach for myocardial infarction (mi), with the aim to solve the delivery challenges that exist with transplanted cells. self assembling peptide (sap) hydrogels comprise a promising class of synthetic biomaterials with cardiac compatible properties such as mild gelation, injectability. Background myofibroblast differentiation, characterized by α smooth muscle actin (α sma) expression, is a key process in organ fibrosis, and is induced by tgf β. here we examined whether an anti fibrotic agent, n acetyl seryl aspartyl lysylproline (ac sdkp), can regulate induction of tgf β signaling and myofibroblast differentiation as a potential key component of its anti fibrotic.
D0 B4 D0 B8 D0 Bf D0 Bb D0 Be D0 Bc D1 8d Biomaterials in conjunction with stem cell therapy have recently attracted attention as a new therapeutic approach for myocardial infarction (mi), with the aim to solve the delivery challenges that exist with transplanted cells. self assembling peptide (sap) hydrogels comprise a promising class of synthetic biomaterials with cardiac compatible properties such as mild gelation, injectability. Background myofibroblast differentiation, characterized by α smooth muscle actin (α sma) expression, is a key process in organ fibrosis, and is induced by tgf β. here we examined whether an anti fibrotic agent, n acetyl seryl aspartyl lysylproline (ac sdkp), can regulate induction of tgf β signaling and myofibroblast differentiation as a potential key component of its anti fibrotic.
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